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25brown bread on white ceramic platesolved 94 times
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36red apple fruit on brown wooden tablesolved 81 times
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25Mountains in Taiwansolved 80 times
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49red inflatable ring on swimming poolsolved 79 times
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36snow covered mountain during sunsetsolved 78 times
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36Water artsolved 76 times
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16Epicviva III: China, The Bronze Agesolved 67 times
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36woman in pink tank top standing in front of waterfallssolved 66 times
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100healthy fruit and vegetablessolved 64 times
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36poached egg with vegetables and tomatoes on blue platesolved 62 times
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100green palm tree on white sand beach during daytimesolved 60 times
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36Sleepy Frogsolved 58 times
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16pink lotus flowerssolved 53 times
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25silhouette of people sitting on rock under starry nightsolved 50 times
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25brown rock formation on blue water during daytimesolved 49 times
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81sliced bread with white icing and black berriessolved 49 times
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81carrots and meat on blue ceramic bowl beside brown breadsolved 46 times
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36green trees on brown rock formation near body of watersolved 45 times
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36Divination, chance in a boxsolved 45 times
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16white and brown long coat small dog on blue concrete floorsolved 43 times
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16Pink Lake, Australiasolved 42 times
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25red coffee latte on white ceramic mugsolved 41 times
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64orange and green vegetables on brown wooden tablesolved 40 times
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49A waterfall flowing into the ocean over cliff.solved 39 times
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64several tomato fruitssolved 39 times
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100sliced bread with sliced tomato and cucumbersolved 39 times
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Abc puzzle huh sliding puzzle online
49Abc puzzle huhsolved 39 times
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white and brown cupcake with strawberry on top online puzzle
16white and brown cupcake with strawberry on topsolved 38 times
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Kitchen appliances sliding puzzle online
25Kitchen appliancessolved 38 times
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palm tree on beach during daytime online puzzle
100palm tree on beach during daytimesolved 38 times
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brown and white round cake sliding puzzle online
81brown and white round cakesolved 36 times
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9body of water during sunsetsolved 36 times
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avocado, tomatoes, eggs, mushrooms, spring onions sliding puzzle online
9avocado, tomatoes, eggs, mushrooms, spring onionssolved 36 times
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baby carrots online puzzle
9baby carrotssolved 35 times
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16red tomatoes on black platesolved 34 times
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Fire making puzzle online puzzle
25Fire making puzzlesolved 34 times
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yellow green blue and red sticks sliding puzzle online
81yellow green blue and red stickssolved 34 times
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klungkung bali indonesia online puzzle
25klungkung bali indonesiasolved 33 times
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green pine trees during snow season online puzzle
64green pine trees during snow seasonsolved 32 times
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red and black train on rail tracks during daytime sliding puzzle online
25red and black train on rail tracks during daytimesolved 31 times
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pink roses on white wooden table sliding puzzle online
9pink roses on white wooden tablesolved 30 times
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Hebrews 12: 11 online puzzle
9Hebrews 12: 11solved 30 times
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brown chocolate on white box sliding puzzle online
9brown chocolate on white boxsolved 29 times
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rock bridge near the village of Tyulenovo sliding puzzle online
36rock bridge near the village of Tyulenovosolved 28 times
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green trees on seashore under blue sky during daytime online puzzle
9green trees on seashore under blue sky during daytimesolved 28 times
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raw meat on chopping board sliding puzzle online
25raw meat on chopping boardsolved 28 times
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sliced orange fruit on brown wooden tray sliding puzzle online
49sliced orange fruit on brown wooden traysolved 27 times
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brown rocks on sea shore during daytime sliding puzzle online
36brown rocks on sea shore during daytimesolved 27 times
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Online puzzle board

Progeria is an extremely rare autosomal dominant genetic disorder in which symptoms resembling aspects of aging are manifested at a very early age. Progeria is one of several progeroid syndromes. Those born with progeria typically live to their mid-teens to early twenties. It is a genetic condition that occurs as a new mutation, and is rarely inherited, as carriers usually do not live to reproduce children. Although the term progeria applies strictly speaking to all diseases characterized by premature aging symptoms, and is often used as such, it is often applied specifically in reference to Hutchinson–Gilford progeria syndrome (HGPS).

Signs and symptoms

Children with progeria usually develop the first symptoms during their first few months of life. The earliest symptoms may include a failure to thrive and a localized scleroderma-like skin condition. As a child ages past infancy, additional conditions become apparent usually around 18–24 months. Limited growth, full-body alopecia (hair loss), and a distinctive appearance (a small face with a shallow recessed jaw, and a pinched nose) are all characteristics of progeria. Signs and symptoms of this progressive disease tend to become more marked as the child ages.