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Progeria is an extremely rare autosomal dominant genetic disorder in which symptoms resembling aspects of aging are manifested at a very early age. Progeria is one of several progeroid syndromes. Those born with progeria typically live to their mid-teens to early twenties. It is a genetic condition that occurs as a new mutation, and is rarely inherited, as carriers usually do not live to reproduce children. Although the term progeria applies strictly speaking to all diseases characterized by premature aging symptoms, and is often used as such, it is often applied specifically in reference to Hutchinson–Gilford progeria syndrome (HGPS). Children with progeria usually develop the first symptoms during their first few months of life. The earliest symptoms may include a failure to thrive and a localized scleroderma-like skin condition. As a child ages past infancy, additional conditions become apparent usually around 18–24 months. Limited growth, full-body alopecia (hair loss), and a distinctive appearance (a small face with a shallow recessed jaw, and a pinched nose) are all characteristics of progeria. Signs and symptoms of this progressive disease tend to become more marked as the child ages.
Valencia, Venezuela - person holding two baseballs. Estadio José Bernardo Pérez, Valencia, Venezuela Solve puzzle
Valencia, Venezuela 9 Piter 0
walking by the fire station - man wearing black hat and white dress shirt walking on street near orange gate. Old Street, London, Solve puzzle
walking by the fire station 16 Bernadetka 0
jeux du Québec - woman in black sports bra and black leggings lying on brown concrete bench. Chicoutimi, Saguenay, QC Solve puzzle
jeux du Québec 49 Felicjusz 0
Male mechanical engineer fits prosthetic limbs - man in blue crew neck shirt holding black smartphone. Solve puzzle
Male mechanical engineer fits prosthetic limbs 64 Klementyna 0
person in white pants and white socks - Aerial (drone) view of Arctic Icebergs. Solve puzzle
person in white pants and white socks 64 Dorothy 0
group of person waving banner - I finally got my chance today to do a bit of reportage at London Fashion Week, where I witnessed a p Solve puzzle
group of person waving banner 25 Edmund 0
man playing basketball - Playing basketball in the street with friends. New York, État de New York, États-Unis Solve puzzle
man playing basketball 64 Karmelia 0
left arm spinner - man in white long sleeve shirt and white pants playing golf during daytime. Boundary Park cricket gr Solve puzzle
left arm spinner 9 Filomena 1
Surveying the Court - girl holding lawn tennis racket while standing beside white and black net. Solve puzzle
Surveying the Court 49 Edmund 0
three football players standing on football field - Boys on the sidelines awaiting their opportunity to play in the homecoming football game - Oxford, A Solve puzzle
three football players standing on football field 64 Ernesto 0
New High Score - man in white crew neck shirt standing near black and white plastic drawer. Oklahoma City, OK, USA Solve puzzle
New High Score 64 Piter 0
Chemical engineers in laboratory - woman in white dress shirt smiling beside woman in white dress shirt. Solve puzzle
Chemical engineers in laboratory 25 Adelajda 0
Field Hockey - person standing behind goal net inside coart. Field Hockey and Lacrosse Complex, College Park, Unite Solve puzzle
Field Hockey 64 Filomena 0
man wearing black cap with love your neighbour print during daytime - This is Max wearing a cap from LOVE YOUR NEIGHBOUR. The label is a social label from Switzerland tha Solve puzzle
man wearing black cap with love your neighbour print during daytime 49 Anastazy 0
Boy Playing cricket. - photography of baseball game. Solve puzzle
Boy Playing cricket. 9 Sergiusz 0
Angry Soccer Player - boy in blue and red jersey shirt holding white soccer ball. Solve puzzle
Angry Soccer Player 25 Rumburak 0
didcot cricket club - man in white shirt and pants playing golf during daytime. Boundary Park cricket ground, Sir Frank Wi Solve puzzle
didcot cricket club 49 Karmelia 0
Family day, Soccer, futbol, - boy in orange shirt and black shorts playing soccer during daytime. South Amboy, NJ, USA Solve puzzle
Family day, Soccer, futbol, 9 Sergiusz 1
Football Match - boy holding soccer ball beside other ball on soccer field. Sant Celoni, Spain Solve puzzle
Football Match 49 Edmund 0
The Last Throw - Lakers player taking technical freethrow. Los Angeles, United States Solve puzzle
The Last Throw 16 Karmelia 0
Icehockey Match Fight - people watching players on ice rink. Solve puzzle
Icehockey Match Fight 16 Klementyna 0
sofia huerta - girls soccer team playing. Maryland SoccerPlex, Boyds, United States Solve puzzle
sofia huerta 9 Piter 1
Volleyball practice game - 2 boys playing volleyball on court. Northeast High School, Cottman Avenue, Philadelphia, PA, USA Solve puzzle
Volleyball practice game 64 Klementyna 0
BaseBall Game - man in blue and white jersey shirt playing basketball. 香港, 香港, 中國香港特別行政區 Solve puzzle
BaseBall Game 64 Gracek 0
Ice Hockey Goalie - ice hockey goalie defending the goal. Planet Ice, South Row, United Kingdom Solve puzzle
Ice Hockey Goalie 9 Ernesto 1
group of men playing football - College quarterback passes the football while his teammates protect him from onrushing opponents. Sh Solve puzzle
group of men playing football 16 Piter 0
Hoya Soccer - goal keeper holding the ball. Shaw Field, washington dc Solve puzzle
Hoya Soccer 16 Piter 0
women's rugby uniforms - Momento en el que una jugadora del Club de Rugby Femenino de Málaga es placada por una jugadora del Solve puzzle
women's rugby uniforms 25 Felicjusz 0
on the front foot - man in white baseball jersey playing golf during daytime. Boundary Park, Sir Frank Williams Avenue, Solve puzzle
on the front foot 9 Gracek 1
defensive - man in white karate gi and white pants running on green grass field during daytime. Boundary Park cr Solve puzzle
defensive 36 Gracek 0
toddler playing football - man in white t-shirt and blue shorts playing soccer during daytime. Willen Lake, Milton Keynes, UK Solve puzzle
toddler playing football 49 Zenek 0
Running in the outfield - baseball player 47 running in field. Solve puzzle
Running in the outfield 25 Zenek 0
Team intros - soccer players on field. Maryland SoccerPlex, Boyds, United States Solve puzzle
Team intros 49 Adelajda 0
Gators Lacrosse - woman lacrosse player running on field at daytime. Field Hockey and Lacrosse Complex, College Park, Solve puzzle
Gators Lacrosse 36 Filomena 0
Basketball court lines - red and yellow concrete floor. Solve puzzle
Basketball court lines 64 Lucjusz 0
More on Instagram! (@wellsjordon) - man in white jersey shirt and shorts running on field during daytime. Solve puzzle
More on Instagram! (@wellsjordon) 16 Rumburak 0
draw control - women's lacrosse competition. Solve puzzle
draw control 49 Sergiusz 0
women playing lacrosse game during daytime - She goes to the goal, nuff said. Pretty cool to get all the water splashing up in air. Field Hockey Solve puzzle
women playing lacrosse game during daytime 36 Zenek 0
Jen Giles. - women playing lacrosse. Field Hockey and Lacrosse Complex, College Park, United States Solve puzzle
Jen Giles. 9 Max 0
man playing tennis in court - Japanese tennis player (China Open). Beijing Solve puzzle
man playing tennis in court 16 Lucjusz 0
Terps Field Hockey - woman playing hockey on fields during daytime. Field Hockey and Lacrosse Complex, College Park, Unit Solve puzzle
Terps Field Hockey 36 Gracek 0
Icehockey Match - person guarding goalie net in field. Solve puzzle
Icehockey Match 16 Edmund 0